A Self-Adjuvanting Large Pore 2D Covalent Organic Framework as a Vaccine Platform.

Vaccines are one of the greatest human achievements in public health, as they help prevent the spread of diseases, reduce illness and death rates, saving thousands of lives with few side effects. Traditional vaccine development is centered around using live attenuated or inactivated pathogens, which is expensive and has resulted in vaccine-associated illnesses. Advancements have led to the development of safer subunit vaccines, which contain recombinant proteins isolated from pathogens.

Molecular Insight into the Interaction between Epigenetics and Leptin in Metabolic Disorders.

Nowadays, it is well-known that the deregulation of epigenetic machinery is a common biological event leading to the development and progression of metabolic disorders. Moreover, the expression level and actions of leptin, a vast adipocytokine regulating energy metabolism, appear to be strongly associated with epigenetics. Therefore, the aim of this review was to summarize the current knowledge of the epigenetic regulation of leptin as well as the leptin-induced epigenetic modifications in metabolic disorders and associated phenomena.

[Diagnostic difficulties in inflammatory-obliterative processes in the posterior cranial fossa in children].

The authors discuss diagnostic difficulties in 3 cases of inflammatory-obliterative processes in the posterior cranial fossa in children. Clinical and other investigations suggested presence of expansive lesions. The diagnosis was established only during the operation.

[Supraventricular subarachnoid cysts].

Five patients with supraventricular subarachnoid cysts are described. In most patients epilepsy was the presenting sign. Cerebral angiography showed in all cases only an avascular lesion and and the correct diagnosis was established only during the operation.