Publications by authors named "K Doser"
Article Synopsis
- Neurofibromatosis type 1 (NF1) is a genetic disorder that can cause various health issues, including cognitive impairments, which are not well-studied in adults; this research focused on evaluating these cognitive issues in adults with NF1.* -
- The study involved 103 NF1 adults and 38 control participants, utilizing a range of neurocognitive tests and a self-report questionnaire to analyze various cognitive functions including intelligence, memory, attention, and executive functions.* -
- Results revealed that adults with NF1 experience significant impairments, particularly in areas like intelligence and visual memory, while some cognitive functions remained intact, suggesting a specific pattern of cognitive deficits rather than a widespread impairment.*
Background: Little is known about employment status, occupation, and disposable income in adults with NF1.
Methods: From the Danish National Patient Registry and database of two national Centers for Rare Diseases, we identified 1469 adults with NF1, who were matched to 11,991 randomly selected population comparisons on sex and birth year and month. Annual information on employment, occupation and disposable income was ascertained from national registries in 1980-2019.
Objective: Previous studies have found that neurofibromatosis 1 (NF1) is associated with an increased risk for endocrine disorders, but no comprehensive overview of the risk for specific endocrine disorders has been published. We assessed endocrine morbidity in individuals with NF1 from information on hospital admissions, surgery for endocrine disorders, and relevant medication.
Design: A nationwide population registry-based cohort study.
Purpose: The Danish neurofibromatosis 1 (NF1) cohort was initiated to study health-related, socioeconomic and psychological consequences of living with the monogenetic disorder NF1 using a nationwide and population-based approach.
Participants: The cohort includes all 2467 individuals in Denmark who were hospitalised with or due to NF1 from 1977 to 2013 or registered in the RAREDIS Database (1995-2013), a national clinical database for rare diseases, or both. A comparison cohort matched to individuals with NF1 on sex and date of birth was identified in the Civil Registration System (n=20 132).
Children with neurofibromatosis 1 (NF1) may have a high burden of somatic disease and cognitive impairments, which can lead to poor academic performance. We evaluated school grades from exams ending mandatory schooling (usually around age 15 or 16 years) of children with NF1 in a population-based registry study using a within-school matched design. The study included 285 children with NF1 and 12,000 NF1-free peers who graduated from the same school and year during 2002-2015.
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