Acute sport-related concussion alters cardiac contribution to cerebral oxygenation during repeated squat stands.

Assessment of cerebral oxygenation during repeated squat stands following an acute sport-related concussion (SRC) has the potential to identify physiological changes following SRC. All varsity university athletes completed a pre-season assessment and 53 were followed up within 5-days of suffering an SRC. Of the 53 participants, 29 had continuous beat-to-beat blood pressure (BP; sampled at 200 hz) collected by finger photoplethysmography, and 53 had right prefrontal cortex oxygenation collected by near-infrared spectroscopy (NIRS; sampled at 10 hz).

Pharmacological and physiological effects of cannabidiol: a dose escalation, placebo washout study protocol.

Background: Cannabinoids such as cannabidiol (CBD) exhibit anti-inflammatory properties and have the potential to act as a therapeutic following mild traumatic brain injury. There is limited evidence available on the pharmacological, physiological and psychological effects of escalating CBD dosages in a healthy, male, university athlete population. Furthermore, no dosing regimen for CBD is available with implications of improving physiological function.

Sport-related concussion alters cerebral hemodynamic activity during controlled respiration.

Sport-related concussion (SRC) is known to disrupt neurohemodynamic activity, cardiac function, and blood pressure (BP) autoregulation. This study aims to observe changes in cerebrovascular and cardiovascular responses during controlled respiration after sustaining an SRC. University varsity athletes ( = 81) completed a preseason physiological assessment and were followed up within 5 days of sustaining an SRC.

Safety of hypoxic red blood cell administration in patients with transfusion-dependent hematological malignancies: An interim analysis.

Anemia is a common symptom of hematological malignancies and red blood cell (RBC) transfusion is the primary supportive treatment, with many patients becoming transfusion dependent. Hemanext Inc. (Lexington, MA, United States) has developed a CE mark certified device to process and store RBCs hypoxically - citrate-phosphatedextrose (CPD)/phosphate-adenine-glucose-guanosine-saline-mannitol (PAGGSM) RBCs, leukocytes-reduced (LR), O/CO reduced - with the aim of improving RBC quality for transfusion.

Differences in Heart Rate Variability and Baroreflex Sensitivity between Male and Female Athletes.

Heart rate variability (HRV), systolic blood pressure variability (BPV), and spontaneous baroreflex sensitivity (BRS) are indirect and approximate measures of autonomic regulation of the cardiovascular system. Studies have shown differences in HRV and BRS between males and females; however, no study has observed differences in BPV, HRV, or BRS between male and female athletes. One hundred males (age 21.