Publications by authors named "K Dore"
Article Synopsis
- The study investigated the effectiveness and safety of the rVSV-ZEBOV vaccine against Zaire Ebolavirus disease among contacts of EVD survivors, focusing on the influence of pre-existing immunity on vaccination outcomes.
- Ten percent of participants had pre-existing antibodies, but both those with and without antibodies showed significant increases in IgG levels post-vaccination, indicating strong immune responses.
- The findings support the vaccine's safety and suggest that pre-vaccination antibody screening is unnecessary, as it does not negatively impact the immune response to the vaccine.
Article Synopsis
- * Recent studies link the disruption of palmitoylation to neurodegenerative diseases, impacting proteins like amyloid precursor protein, BACE1, and others involved in neuronal dysfunction.
- * The review discusses new findings on palmitoylation's role in neurodegeneration and investigates potential treatments that could target this process.
NMDA-type glutamate receptors (NMDARs) are widely recognized as master regulators of synaptic plasticity, most notably for driving long-term changes in synapse size and strength that support learning. NMDARs are unique among neurotransmitter receptors in that they require binding of both neurotransmitter (glutamate) and co-agonist (e.g.
View Article and Find Full Text PDFThe relative amount of AMPA receptors expressed at the surface of neurons can be measured using superecliptic pHluorin (SEP) labeling at their N-terminus. However, the high signal variability resulting from protein overexpression in neurons and the low signal observed in intracellular vesicles make quantitative characterization of receptor trafficking difficult. Here, we establish a real-time live-cell assay of AMPAR trafficking based on fluorescence lifetime imaging (FLIM), which allows for simultaneous visualization of both surface and intracellular receptors.
View Article and Find Full Text PDFUnlabelled: NMDA-type glutamate receptors (NMDARs) are widely recognized as master regulators of synaptic plasticity, most notably for driving long-term changes in synapse size and strength that support learning. NMDARs are unique among neurotransmitter receptors in that they require binding of both neurotransmitter (glutamate) and co-agonist (e.g.
View Article and Find Full Text PDF