Publications by authors named "K Donnelly"
Article Synopsis
- Common genetic variation at the 11q23.1 locus is linked to colorectal cancer risk, complicating the understanding of its mechanisms due to complex gene interactions and expression patterns.
- The study utilizes various sequencing methods and mouse models to identify key genes, especially highlighting rs3087967 as a crucial variant that influences the expression of 21 genes associated with tuft cell markers.
- The findings suggest that the risk genotype at rs3087967 leads to a deficiency in tuft cells, which are important for tumor suppression, positioning these cells as protective elements in colorectal cancer development.
Preoperative checklists have demonstrated efficacy in improving patient care in the surgical setting. While the assessment of perioperative risks through patient inquiry is extensive, the menstrual status of the patient is one question that is not frequently discussed. If a patient is menstruating during their surgical procedure, unknown use of an intravaginal menstrual hygiene product, such as a tampon or menstrual cup, places the patient at risk of infection.
View Article and Find Full Text PDFBackground: Social isolation and loneliness have both been associated with psychological health and cognitive decline in older adults. This study investigated the impact of social interaction through remote communication technologies during the COVID-19 pandemic on the cognitive and psychological status of older adults with and without cognitive impairment.
Methods: Participants were recruited from Boston (USA) and Chieti (Italy).
Article Synopsis
- Biologic treatments have shown promise in achieving complete skin clearance for moderate to severe plaque psoriasis, with bimekizumab demonstrating superior efficacy compared to other treatments like secukinumab, adalimumab, and ustekinumab in clinical trials.
- A systematic literature review and network meta-analysis evaluated 19 randomized controlled trials to compare the efficacy and safety of bimekizumab against other biologic therapies over one year, focusing on improvements in the Psoriasis Area and Severity Index (PASI).
- The results indicated that bimekizumab 320 mg given every 4 weeks, then every 8 weeks, was more effective in achieving complete skin clearance compared to most other biologics, particularly highlighting the efficacy
Article Synopsis
- - Resilience plays a significant role in how post-concussion symptoms (PCS) are experienced, especially among minority women who often face longer recovery times from concussions.
- - A study involving 77 women found a moderate negative association between resilience and PCS, with stronger effects observed in Black participants compared to other races.
- - Interventions aimed at enhancing resilience should also address mood, as both were found to independently impact PCS resolution, suggesting that this dual focus could improve recovery outcomes for minority women experiencing concussions.