Publications by authors named "K Donahue"
Background: Rates of in-hospital venous thromboembolism (VTE) in the intracranial hemorrhage (ICH) population post oral anticoagulation (AC) reversal are as high as 10%. Guidelines recommend the initiation of prophylactic AC 24 to 48 hours post ICH; however, there is no guidance regarding optimal VTE prophylaxis post-reversal.
Objective: This study aimed to identify the incidence of thromboembolism post oral AC reversal in patients presenting with ICH and describe VTE prophylaxis timing and agent selection.
Article Synopsis
- Printed electronics is a game-changing technology used in various applications such as sensors, displays, and wearable devices, utilizing 2D materials for their excellent properties.
- Traditional methods for producing 2D electronic inks, like centrifugation, are time-consuming and inefficient, while newer methods face challenges due to low concentration requirements.
- The presented study introduces a continuous flow system using advanced ceramic membranes that enhance processing efficiency, significantly reduce environmental impact, and lower production costs for high-quality printable inks.
Activated partial thromboplastin time (aPTT) and unfractionated heparin (UFH) level via the anti-factor Xa activity assay (anti-Xa) are commonly used assays for UFH monitoring. While discordance between the two assays is common, its impact on critically ill patient outcomes is unclear. This study aimed to compare the incidence of major bleeding events among critically ill patients with discordant aPTT and anti-Xa activity while on UFH, to patients with no discordance.
View Article and Find Full Text PDFThe COVID-19 pandemic highlights the ongoing risk of zoonotic transmission of coronaviruses to global health. To prepare for future pandemics, it is essential to develop effective antivirals targeting a broad range of coronaviruses. Targeting the essential and clinically validated coronavirus main protease (M), we constructed a structurally diverse M panel by clustering all known coronavirus sequences by M active site sequence similarity.
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