Tumour stage distribution and survival of malignant melanoma in Germany 2002-2011.

Background: Over the past two decades, there has been a rising trend in malignant melanoma incidence worldwide. In 2008, Germany introduced a nationwide skin cancer screening program starting at age 35. The aims of this study were to analyse the distribution of malignant melanoma tumour stages over time, as well as demographic and regional differences in stage distribution and survival of melanoma patients.

Expression profiles for 14-3-3 zeta and CCL20 in pancreatic cancer and chronic pancreatitis.

Background: Pancreatic cancer (PCA) has a dismal prognosis because it is often diagnosed at an advanced stage. The overall survival rate is <5% after five years. Chronic pancreatitis (CP) is one of the most important risk factors for PCA.

[Primary metastatic well-differentiated neuroendocrine tumor arising in a tailgut cyst].

Tailgut cysts are unusual benign cystic retrorectal malformations arising from persistent remnants of the postanal gut. Malignant transformation within this dysontogenetic lesion is very uncommon. We report the rare occurrence of a neuroendocrine tumor arising in a tailgut cyst with primary liver and lymph node metastases in a 55-year-old woman.

[Juvenile gastric polyposis: differential diagnosis for recurrent nausea, vomiting, upper abdominal pain and diarrhoea].

History And Admission Findings: A 46-year-old woman presented with nausea and vomiting, colics and localized pain in the upper abdomen. There was a family history of juvenile polyposis (3 of 4 siblings). Twelve years ago a colectomy had been performed in the patient for a gastric mucosal polyps.

[Practical neoadjuvant and adjuvant therapies for rectal cancer. How many patients are actually recruited in multimodality therapy concepts? An analysis of the Tumour Centre Schwerin].

Introduction: For rectal cancer in UICC stage II or III, a neoadjuvant chemoradiotherapy or short-course radiotherapy is established to reduce the incidence of local relapses. It has been documented that the neoadjuvant therapy is superior to the adjuvant therapy. In spite of the formulation of therapeutic principles in guidelines, they are not consistently applied.