Experimental atherosclerosis model in domestic pigs. Part II. Electrocardiographic and morphologic investigation.

Experimental atherosclerosis was produced in domestic pigs by administration for 24 weeks a high lipid diet containing cholesterol and coconut oil. ECG changes were not uniform: negative T, prolonged intraventricular conduction, and premature ventricular beats were observed. Macroscopic and microscopic anatomo-pathological studies revealed atheromatous changes in the aorta.

Histologic changes in the spleen of rabbits following long-term and multiple immunization with sheep red blood cells.

Results of immunologic and histologic studies on rabbits immunized with sheep red blood cells (SRBC) showed dependence of the immunologic response (PFC, RFC) on the histologic structure of the spleen, particularly width of the sinusoidal vessels. Histologic changes in the spleen are a result of immunization and their intensity is related to the dose of antigen. The influence of dosage of antigen and histologic structure of the spleen on regulation of the immunologic response are discussed.