Cochlear-implant simulated spectral degradation attenuates emotional responses to environmental sounds.

Objective: Cochlear implants (CI) provide users with a spectrally degraded acoustic signal that could impact their auditory emotional experiences. This study evaluated the effects of CI-simulated spectral degradation on emotional valence and arousal elicited by environmental sounds.

Design: Thirty emotionally evocative sounds were filtered through a noise-band vocoder.

Outreach, Screening, and Randomization of APOE ε4 Carriers into an Alzheimer's Prevention Trial: A global Perspective from the API Generation Program.

Background: Alzheimer's disease (AD) prevention trials require a large outreach and screening funnel to identify cognitively unimpaired adults who meet the study's inclusion criteria, such as certain clinical or demographic criteria, genetic risk factors, and/or biomarker evidence of the disease.

Objectives: Describe tactics and strategies to identify and enroll cognitively unimpaired adults with one (heterozygotes [HT]) or two (homozygotes [HM]) copies of the APOE ε4 allele, a genetic risk factor for dementia due to AD, into the Alzheimer's Prevention Initiative (API) Generation Program, the largest and only prevention trials for late onset AD using this enrichment technique.

Design And Setting: The Generation Program was comprised of two global, randomized, double-blind, placebo-controlled, parallel group adaptive design with variable treatment duration clinical trials.

Bioavailability of phenytoin acid and phenytoin sodium with enteral feedings.

Study Objective: To compare the absolute bioavailability of phenytoin (PHT) sodium solution and PHT acid suspension in healthy volunteers receiving continuously infused enteral feedings.

Design: Randomized, open-label, single-dose, three-period crossover study.

Setting: University clinical research center.