Publications by authors named "K Dhandapani"
Article Synopsis
- Ischemic stroke can lead to severe disability and death, and researchers are investigating how the timing of a stroke impacts its severity, particularly focusing on the circadian clock protein Rev-Erbα.
- A study found that administering SR9009, a Rev-Erbα agonist, significantly reduced neuroinflammation and infarct size in mice when treated at specific times (ZT06 - during sleep) but not at other times (ZT18 - during wakefulness).
- The results suggest that SR9009 alters immune responses and may offer therapeutic benefits for stroke treatment, emphasizing the importance of timing in administering interventions.
Background: Rotator cuff tears can lead to debilitating shoulder function and impairment. Rotator cuff repair aims to eliminate pain and improve function with increased shoulder strength and range of motion. This study evaluated the differences between all-arthroscopic (AA) and mini-open (MO) repair procedures for rotator cuff tendon tears regarding clinical and functional outcomes.
View Article and Find Full Text PDFAlzheimer's disease (AD) is a challenging medical issue that requires efficacious treatment options to improve long-term quality of life. Cannabidiol (CBD) is a cannabis-derived phytocannabinoid with potential health benefits, including reports from our laboratory and others showing a therapeutic role in the pre-clinical treatment of AD; however, the mechanisms whereby CBD affects AD progression remain undefined. Innate lymphoid cells (ILCs) are recently discovered immune cells that initiate and orchestrate inflammatory responses.
View Article and Find Full Text PDFIntroduction: Human factors in surgery relate to the environmental, organisational, and human factors that can impact performance in the operating theatre. This study assesses whether various factors such as music, counting backwards, and attempting to do simultaneous tasks impact surgical time and performance.
Methods: Ten orthopaedic surgical staff were asked to guide a metal loop around a metal maze in a 'don't buzz the wire' game.
Article Synopsis
- - The study focused on evaluating the outcomes of arthroscopic single-bundle ACL reconstruction, highlighting its role in restoring knee stability after ACL tears, which can lead to joint changes if untreated.
- - Conducted in Kolkata, India, the study involved 45 patients with a follow-up period of at least nine months, revealing that 93.34% had excellent to good recovery and a high average Lysholm knee score of 95.31.
- - The findings concluded that this surgical technique using hamstring autograft is an effective treatment, allowing patients to return to their pre-injury activity levels without significant complications or long-term disabilities.