Crystal structure, optical properties, DFT analysis of new morpholine based Schiff base ligands and their copper(II) complexes: DNA, protein docking analyses, antibacterial study and anticancer evaluation.

New morpholine derived Schiff base ligands (HL and HL) and their Cu(II) complexes [Cu(L)] (1) and [Cu(L)] (2) have been synthesized and characterized by H NMR, IR, UV-Vis, EPR studies and cyclic voltammetric analyses. Single crystal X-ray crystallography studies confirm the structure of newly synthesized Schiff base ligands HLand HL. The ground state electronic structures of Cu(II) complexes 1 and 2 have been investigated by DFT/B3LYP theoretical analysis with 6-31G (d,p) and LANL2DZ basis set.

Synthesis, characterization, crystal structure and cytotoxic properties of thiosemicarbazide Ni(II) and Zn(II) complexes.

Synthesis of new complexes of Ni(II) (1) and Zn(II) (2) with [1-(2-hydroxy-3,5-diiodobenzylidene)-4-phenylthiosemicarbazide] have been reported. The composition of these two complexes 1 and 2 is discussed on the basis of IR, (1)H NMR and UV spectral data along with their X-ray crystallographic data. The crystal structure of these two complexes has revealed that the free ligand (L) is deprotonated twice at the oxygen and sulfur atoms and they are coordinated with the complexes through phenoxide-O, azomethine-N and thiolate-S atoms.

Synthesis and spectral characterization of Schiff base complexes of Cu(II), Co(II), Zn(II) and VO(IV) containing 4-(4-aminophenyl)morpholine derivatives: antimicrobial evaluation and anticancer studies.

Metal(II) chelates of Schiff bases derived from the condensation of 4-morpholinoaniline with substituted salicylaldehyde have been prepared and characterized by (1)H NMR, IR, electronic, EPR, and magnetic measurement studies. The complexes are of the type M(X-MPMP)2 [where M=Cu(II), Co(II)), Zn(II), or VO(IV); MPMP=2-[(4 morpholinophenyl imino) methyl] 4-X-phenol, X=Cl, (L1H), X=Br (L2H)]. Single crystal X-ray crystallography studies confirm the structure of newly synthesized Schiff bases.

5-Meth-oxy-2-{[4-(morpholin-4-yl)phen-yl]imino-meth-yl}phenol.

In the title compound, C(18)H(20)N(2)O(3), the dihedral angle between the two aromatic rings is 33.66 (6)°. The morpholine ring adopts a chair conformation.