Publications by authors named "K Dettmer"
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) presents significant challenges for affected children and adolescents, their social environment, and treating physicians, due to its profound impact on quality of life and the lack of causal therapeutic approaches. One crucial aspect of care that has been missing for these patients is comprehensive education for both them and their social circles.
Objective: This study protocol aims to outline the goals, study design, execution, and evaluation of the subproject within the BAYNET FOR ME/CFS project.
Despite recent treatment advances, non-small cell lung cancer (NSCLC) remains one of the leading causes of cancer-related deaths worldwide, and therefore it necessitates the exploration of new therapy options. One commonly shared feature of malignant cells is their ability to hijack metabolic pathways to confer survival or proliferation. In this study, we highlight the importance of the polyol pathway (PP) in NSCLC metabolism.
View Article and Find Full Text PDFAconitate decarboxylase-1 (ACOD1) is expressed by activated macrophages and generates itaconate that exerts anti-microbial and immunoregulatory effects. ACOD1-itaconate is essential for macrophage-mediated control of the intracellular pathogen , which causes Q fever. Two isomers of itaconate, mesaconate and citraconate, have overlapping yet distinct activity on macrophage metabolism and inflammatory gene expression.
View Article and Find Full Text PDFIt was pointed out to us that we had not followed exactly the IROA TruQuant IQQ Workflow Kit protocol in the experimental part of our work [...
View Article and Find Full Text PDFArticle Synopsis
- The study explores the role of CD101, an immunoglobulin-like glycoprotein, in T lymphocytes and myeloid cells during intestinal diseases like colitis and Salmonella infections.
- CD101 deficiency in regulatory T cells led to worsened intestinal damage in both colitis and Salmonella models, highlighting its importance in mediating immune responses.
- The research reveals that CD101 helps control Salmonella infections through specific immune mechanisms and that its expression in myeloid cells is reduced in inflammatory bowel disease, suggesting a link between CD101 and immune regulation in these conditions.