Publications by authors named "K Deiva"
Long-Term Clinical and Biological Prognostic Factors of Anti-NMDA Receptor Encephalitis in Children.
Neurol Neuroimmunol Neuroinflamm
March 2025
Background And Objectives: Anti-NMDAR encephalitis (NMDARE) is a severe neurologic condition, and recently, the NMDAR Encephalitis One-Year Functional Status (NEOS) score has emerged as a 1-year prognostic tool. This study aimed to evaluate NEOS score and biomarker (neurofilament light chains [NfL], total-Tau protein, glial fibrillary acidic protein, and serum cytokines) correlation with modified Rankin Scale (mRS), cognitive impairment, and clinical recovery in pediatric NMDARE over 2 years.
Methods: In this French multicenter observational study, 104 pediatric patients with NMDARE were followed for a minimum of 2 years.
Spectrum of Clinical and Imaging Features of Children With GFAP Astrocytopathy.
Neurol Neuroimmunol Neuroinflamm
January 2025
Article Synopsis
- This study investigates the clinical and MRI characteristics of children with autoimmune GFAP astrocytopathy, revealing limited data compared to what is known in adults.
- Researchers analyzed cases of 15 children from various clinical centers, finding common symptoms like acute encephalitis and meningitis, and specific MRI patterns in all cases.
- The findings suggest that GFAP antibodies lead to distinct clinical and imaging features, emphasizing the need for testing in pediatric patients with similar symptoms, especially those with brainstem involvement.
Long-term follow-up MR imaging in children with transverse myelitis.
Mult Scler Relat Disord
December 2024
Article Synopsis
- The study investigates how lesions in children with transverse myelitis (TM) resolve over time, focusing on different related diseases: MOG-antibody associated disorders (MOGAD), multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and double seronegative TM.
- A total of 78 children from various medical centers were assessed, and a grading system was used to measure the resolution of lesions over time.
- Results showed that MOGAD had the fastest and most complete resolution of lesions, followed by double seronegative TM, MS, and NMOSD, with none of the NMOSD patients achieving complete resolution during the observation period.
Article Synopsis
- The study aimed to assess how paediatric myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) affects children's academic and cognitive performance.
- It involved a review of 51 pediatric cases, revealing that 39.5% of patients required educational interventions, with average IQ scores lower than the general population.
- The findings suggest that children with MOGAD often need additional academic support and should undergo cognitive assessments to help plan their educational needs.
Background: Multiple sclerosis (MS) may occur before the age of 18. Differentiation between paediatric MS (PedMS) and other demyelinating syndromes (ODSs) is challenging. In adult with MS, the kappa free light chain (KFLC) index has proven to be a reliable marker of intrathecal Ig synthesis.
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