Publications by authors named "K Dee Carey"
Background: Non-invasive ventilation (NIV) uses positive pressure to assist people with respiratory muscle weakness or severe respiratory compromise to breathe. Most people use this treatment during sleep when breathing is most susceptible to instability. The benefits of using NIV in motor neurone disease (MND) are well-established.
View Article and Find Full Text PDFSeveral transcription inhibitors have been developed as cancer therapies. However, they show modest clinical activity, highlighting that our understanding of the cellular response to transcriptional inhibition remains incomplete. Here we report that potent inhibitors of transcription not only impact mRNA output but also markedly impair mRNA transcript localization and nuclear export.
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- Young adults who drink heavily often face both positive and regretted romantic or sexual experiences, with gender and past sexual assault possibly influencing these experiences.
- The study involved 201 young adults who reported high drinking habits, tracking their alcohol and cannabis use alongside their romantic encounters over 29 days.
- Results showed that drinking more increased both positive and regretted experiences, with simultaneous alcohol and cannabis use generally not affecting positive experiences; however, it decreased the likelihood of regretted experiences for women, suggesting a protective effect that was not seen for men.
Article Synopsis
- High-grade serous ovarian cancer (HGSOC) is a complex and aggressive cancer type marked by significant molecular diversity, challenging current treatment efforts.
- This study analyzed four mRNA subtypes—immunoreactive, differentiated, proliferative, and mesenchymal—focusing on their gene expression profiles, immune microenvironment, and connections to clinical traits like survival and age.
- Key findings showed that the immunoreactive subtype had high immune cell infiltration linked to better immune responses, while the proliferative subtype was associated with growth and cancer progression, highlighting the need for subtype-specific treatment strategies.
Detection of Real-Time Changes in Direction of COVID-19 Transmission Using National- and State-Level Epidemic Trends Based on R Estimates - United States Overall and New Mexico, April-October 2024.
MMWR Morb Mortal Wkly Rep
November 2024
Public health practitioners rely on timely surveillance data for planning and decision-making; however, surveillance data are often subject to delays. Epidemic trend categories, based on time-varying effective reproductive number (R) estimates that use nowcasting methods, can mitigate reporting lags in surveillance data and detect changes in community transmission before reporting is completed. CDC analyzed the performance of epidemic trend categories for COVID-19 during summer 2024 in the United States and at the state level in New Mexico.
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