Functional interpretations of sadness, stress and demoralization among an urban population of low-income mothers.

Objectives: We sought to understand how low-income urban mothers explain feelings of sadness, stress or demoralization in the context of their life experiences.

Methods: 28 in-depth qualitative interviews, constituting part of a community-based participatory research (CBPR) project aimed at developing a culturally relevant, community-based intervention for maternal depression. Qualitative data validity was ensured through investigator and expert triangulation, and through member checking.

"You get what you get": unexpected findings about low-income parents' negative experiences with community resources.

Context: Community-based resources are considered a critical part of the American health care system. However, studies evaluating the effectiveness of such resources have not been accompanied by rigorous explorations of the perceptions or experiences of those who use them.

Objectives: We aimed to understand and classify types of negative perceptions that low-income parents have of community resources.

Impaired medial temporal repetition suppression is related to failure of parietal deactivation in Alzheimer disease.

Objectives: Neural networks supporting encoding of new information are affected early in the course of Alzheimer disease (AD). Functional magnetic resonance imaging (fMRI) studies in AD have reported decreased medial temporal lobe (MTL) activation when comparing novel versus repeated stimuli. It is, however, unclear whether this finding is related to a failure of normal suppression of MTL activity to repeated stimuli in AD.

Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation.

The neural underpinnings of age-related memory impairment remain to be fully elucidated. Using a subsequent memory face-name functional MRI (fMRI) paradigm, young and old adults showed a similar magnitude and extent of hippocampal activation during successful associative encoding. Young adults demonstrated greater deactivation (task-induced decrease in BOLD signal) in medial parietal regions during successful compared with failed encoding, whereas old adults as a group did not demonstrate a differential pattern of deactivation between trial types.

Relationship of fMRI activation to clinical trial memory measures in Alzheimer disease.

Background: Functional MRI (fMRI) has shown promise as a tool to characterize altered brain function in Alzheimer disease (AD) and for use in proof of concept clinical trials. FMRI studies of subjects with AD have demonstrated altered hippocampal and neocortical activation while encoding novel stimuli compared to older controls. However, the relationship between fMRI activation and performance on standardized clinical trial memory measures has not been fully investigated.