Publications by authors named "K De Witte"
During recent decades, changes in lifestyle have led to widespread nutritional obesity and its related complications. Remodelling adipose tissue as a therapeutic goal for obesity and its complications has attracted much attention and continues to be actively explored. The endothelium lines all blood vessels and is close to all cells, including adipocytes.
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- Women with heart failure and reduced ejection fraction (HFrEF) experience more severe symptoms and a lower quality of life than men, potentially linked to differences in skeletal muscle pathology between the sexes.
- A study analyzed muscle biopsies from men and women with HFrEF, revealing significant differences in gene expression, muscle fiber types, and inflammatory markers, including 5629 differentially expressed genes.
- Results indicated that men had more proatrophic gene expression and muscle abnormalities, while women displayed a pro-oxidative muscle phenotype with greater muscle capillarity and higher density of type I fibers.
We aimed to describe the safety and tolerability of initiation of sodium-glucose cotransporter 2 inhibitors (SGLT2i) during hospitalisation with heart failure, and the frequency of, and reasons for, subsequent discontinuation. In total, 934 patients who were not already prescribed a SGLT2i were hospitalised with heart failure, 77 (8%) were initiated on a SGLT2i a median of five (3-8.5) days after admission and two (0.
View Article and Find Full Text PDFIndividuals with pacemakers are at increased risk of left ventricular systolic dysfunction (LVSD). Whether screening for and optimizing the medical management of LVSD in these individuals can improve clinical outcomes is unknown. In the present study, in a multicenter controlled trial (OPT-PACE), we randomized 1,201 patients (717 men) with a pacemaker to echocardiography screening or usual care.
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