Publications by authors named "K De Luca"

Background: Diagnostic imaging is commonly used in the management of low back pain (LBP), with approximately one-quarter of those who present to primary care referred for imaging. Current estimates of imaging frequency commonly exclude older adults; however, pathology detected with imaging (e.g.

View Article and Find Full Text PDF

To investigate the dosimetric impact of laterality-specific RapidPlan models for nonsmall cell lung cancer. Three RapidPlan models were developed and validated for Right, Left, and General conventional lung radiotherapy. Each model was trained using 50 plans.

View Article and Find Full Text PDF
Article Synopsis
  • DNA damage repair is essential for genomic integrity and cellular health, but detecting it in individual cells has been challenging.
  • The study uses innovative techniques (DamID and ChIC sequencing) to analyze how repair proteins localize in response to DNA double-strand breaks, revealing variability in damage locations and repair features.
  • Findings indicate that repair proteins cluster in large chromatin hubs, enhancing their coordination and suggesting a preference for cooperative repair mechanisms across the genome.
View Article and Find Full Text PDF

This study investigated optimization settings that steepen the dose gradient as a function of target size for lung stereotactic body radiation therapy (SBRT). Sixty-eight lung SBRT patients with planning target volumes (PTVs) ranging from 2-203 cc were categorized into small (<20 cc), medium (20-50 cc), and large (>50 cc) groups. VMAT plans were generated using the normal tissue objective (NTO) to penalize the dose gradient at progressively steeper NTO fall-off values (0.

View Article and Find Full Text PDF

This study investigated a straightforward treatment planning technique for definitive stereotactic body radiation therapy (SBRT) for patients with early-stage lung cancer aimed at increasing dose to gross disease by strategically penalizing the normal tissue objective (NTO) in the Eclipse treatment planning system. Twenty-five SBRT cases were replanned to 50 Gy in 5 fractions using static and dynamic NTO methods (50 plans total). The NTO had a start dose of 100% at the target border, end dose of 20%, fall-off rate of 0.

View Article and Find Full Text PDF