Accelerated Continuous Flow Depolymerization of Poly(Methyl Methacrylate).

A continuous flow setup comprising an inline dialysis unit for immediate monomer removal is used for the depolymerization of poly(methyl methacrylate) (pMMA), synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The approach used allows one to carry out solution depolymerizations at much higher polymer content compared to batch processes while maintaining high depolymerization conversions. pMMA is efficiently depolymerized in the flow reactor, yielding up to 68% monomer recovery under catalyst-free reaction conditions at 160 °C, starting from a 1 molar repeat unit concentration, which is a 20-fold improvement compared to previous batch studies.

Longitudinal serum bicarbonate and mortality risk in older patients with advanced chronic kidney disease: analyses from the EQUAL cohort.

Background: We aimed to explore the relationship between serum bicarbonate (SBC) and mortality in advanced chronic kidney disease (CKD) during three distinct treatment periods: during the pre-kidney replacement therapy (KRT) period, during the transition phase surrounding the start of KRT (transition-CKD) and during KRT.

Methods: Using the European QUALity Study on treatment in advanced CKD (EQUAL) cohort, which includes patients aged ≥65 years and estimated glomerular filtration rate (eGFR) ≤20 mL/min/1.73 m from six European countries, we explored the association between longitudinal SBC and all-cause mortality in three separate CKD populations: pre-KRT, transition-CKD and in the KRT populations, using multivariable time-dependent Cox regression models.

Prescribing patterns in older people with advanced chronic kidney disease towards the end of life.

Background: Advancing age and chronic kidney disease (CKD) are risk factors for polypharmacy. Polypharmacy is associated with negative healthcare outcomes. Deprescribing, the systematic rationalization of potentially inappropriate medications, is a proposed way of addressing polypharmacy.

Psychometric properties of the Dutch version of the revised neurophysiology of pain questionnaire.

Background: Understanding pain and its mechanisms can play an important role in (post-) cancer rehabilitation. In order to test patient's knowledge of pain, the Revised Neurophysiology of Pain Questionnaire was developed and translated into Dutch (RNPQ-NL). However, its psychometric properties have not been examined yet.