Publications by authors named "K Dams-O'Connor"
Background: Some evidence supports an association between traumatic brain injury (TBI) and greater risk of dementia, but the role of cognitive resilience in this association is poorly understood.
Method: 2,050 participants from the Framingham Heart Study Offspring cohort who were aged ≥60 year and had a plasma total tau (t-tau) measure at Exam 8 (2005-2008), and a neuropsychological (NP) exam visit within five years were included. Plasma t-tau was measured using the Simoa assay (Quanterix).
This session is proposed for consideration to be presented as part of the Partnering with Research Participants Professional Interest Area (PIA), for AAIC 2024 FRS titled Participant and Public Involvement Across Alzheimer's Disease Research Studies: Conceptual and Empirical Strategies for Equitable Participation. This session will focus on areas of opportunity in the involvement of research volunteers to further and enhance research design and practices in different aspects of AD and ADRD research studies. This session is specifically focused on conceptual and applied approaches for the involvement of research volunteers across all study designs.
View Article and Find Full Text PDFBackground: Although traumatic brain injury (TBI) is known to be associated with short term mortality, its effects on long-term mortality remain less clear. TBI is also a well-known risk factor for dementia. We hypothesized that TBI would be associated with long-term mortality, particularly dementia-related mortality.
View Article and Find Full Text PDFTraumatic brain injury (TBI) and subsequent post-traumatic epilepsy (PTE) often impair daily activities and mental health (MH), which contribute to long-term TBI-related disability. PTE also affects driving capacity, which impacts functional independence, community participation, and satisfaction with life (SWL). However, studies evaluating the collective impact of PTE on multidimensional outcomes are lacking.
View Article and Find Full Text PDFArticle Synopsis
- Recent autopsy studies show that interface astroglial scarring (IAS) can occur at the gray-white matter junction in military personnel who experience repeated blast brain injuries.
- There is currently no neuroimaging test available to detect IAS, making it difficult to diagnose and treat these injuries.
- In a study of 27 U.S. Special Operations Forces personnel, five individuals (18.5%) showed elevated neuroinflammation signals at the gray-white matter interface compared to healthy controls, suggesting that TSPO PET scans may help identify repeated blast brain injury.