Exhaled ethane concentration in patients with cancer of the upper gastrointestinal tract - a proof of concept study.

There has been growing interest in the measurement of breath ethane as an optimal non-invasive marker of oxidative stress. High concentrations of various breath alkanes including ethane have been reported in a number of malignancies. Our aim was to investigate the use of novel laser spectroscopy for rapid reporting of exhaled ethane and to determine whether breath ethane concentration is related to a diagnosis of upper gastrointestinal malignancy.

Breath ethane peaks during a single haemodialysis session and is associated with time on dialysis.

There is growing evidence that oxidative stress is increased in haemodialysis patients and that dialysis per se is a contributory factor. The elevated oxidant stress, a result of increased production of reactive oxidant species (ROS), may be due to increased pro-inflammatory activity and reduced antioxidant mechanisms. ROS are transitory molecules and therefore surrogate markers of oxidant damage are required.

Response of a Fabry-Perot optical cavity to phase modulation sidebands for use in electro-optic control systems.

The worldwide endeavor to build long baseline laser interferometers to detect and study gravitational radiation is well under way. In the German-British GEO600 project, it is proposed to pass the sidebands induced on the light by an electro-optic phase modulator through a Fabry-Perot optical cavity used in transmission, called a mode cleaner. This can be achieved when the phase modulation frequency is matched to the first longitudinal-mode frequency of the mode cleaner cavity so that both carrier and sidebands are transmitted.

Dynamic study of oxidative stress in renal dialysis patients based on breath ethane measured by optical spectroscopy.

The application of optical spectroscopy for rapid accurate measurement of breath biomarkers has opened up new possibilities for monitoring and diagnostics in recent years. Here, we report on how our recent advances in optical detection of ethane have enabled us to record dynamic breath ethane patterns for patients undergoing kidney dialysis. Ethane is well established as a breath biomarker for free radical induced cell degradation.