What is the best brain state to predict autistic traits?

Autism is a heterogeneous condition, and functional magnetic resonance imaging-based studies have advanced understanding of neurobiological correlates of autistic features. Nevertheless, little work has focused on the optimal brain states to reveal brain-phenotype relationships. In addition, there is a need to better understand the relevance of attentional abilities in mediating autistic features.

Neurobiological Mechanisms Underlying Psychological Dysfunction After Brain Injuries.

Despite the presentation of similar psychological symptoms, psychological dysfunction secondary to brain injury exhibits markedly lower treatment efficacy compared to injury-independent psychological dysfunction. This gap remains evident, despite extensive research efforts. This review integrates clinical and preclinical evidence to provide a comprehensive overview of the neurobiological mechanisms underlying neuropsychological disorders, focusing on the role of key brain regions in emotional regulation across various forms of brain injuries.

Development and evaluation of a 4M taxonomy from nursing home staff text messages using a fine-tuned generative language model.

Objective: This study aimed to explore the utilization of a fine-tuned language model to extract expressions related to the Age-Friendly Health Systems 4M Framework (What Matters, Medication, Mentation, and Mobility) from nursing home worker text messages, deploy automated mapping of these expressions to a taxonomy, and explore the created expressions and relationships.

Materials And Methods: The dataset included 21 357 text messages from healthcare workers in 12 Missouri nursing homes. A sample of 860 messages was annotated by clinical experts to form a "Gold Standard" dataset.

Going commando as part of a multifaceted intervention to reduce CAUTIs in critically ill children.

This project was initiated in a large pediatric intensive care unit to reduce catheter-associated urinary tract infections (CAUTIs). Implementing removal of diapers and a urine collection device that prevented urine backflow in March 2021 decreased the rate from 3.3 to 0.