Dementia Care Practice.

Engagement of People with Lived Experience of Dementia (EPLED) was a new cross-cutting program introduced as part of the Canadian Consortium on Neurodegeneration in Aging (CCNA) for their second 5-year phase (from 2019 to 2024). The initiative was supported by the Alzheimer Society of Canada as part of their commitment to the CCNA. EPLED had three objectives: (1) support persons with dementia and care partners to be actively involved in the CCNA research process; (2) work with CCNA research Teams, Cross-cutting Programs and Partners to develop novel mechanisms and formats to further this collaboration; and, (3) advance the methods of patient engagement in research by embedding evaluation.

RB-TnSeq barcode abundance data sets for grown on the β-5-linked aromatic dimer dehydrodiconiferyl alcohol.

A randomly barcoded transposon insertion sequencing (RB-TnSeq) library of DSM12444 was grown in media containing either glucose or the β-5-linked aromatic dimer dehydrodiconiferyl alcohol (DC-A) as the sole carbon source. The cultures were grown to saturation and then sequenced, yielding the barcode abundance data sets presented here.

SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia.

SUMOylation, the covalent attachment of the small ubiquitin-like modifier (SUMO) to target proteins, and its reversal, deSUMOylation by SUMO proteases like Sentrin-specific proteases (SENPs), are crucial for initiating cellular responses to hypoxia. However, their roles in subsequent adaptation processes to hypoxia such as mitochondrial autophagy (mitophagy) remain unexplored. Here, we show that general SUMOylation, particularly SUMO2/3 modification, suppresses mitophagy under both normoxia and hypoxia.