Publications by authors named "K D Mueller"
Background: Obstructive hypertrophic cardiomyopathy (HCM) is associated with significant morbidity due to left ventricular outflow tract (LVOT) obstruction. While alcohol septal ablation (ASA) is an established interventional treatment, mavacamten, a novel cardiac myosin inhibitor, has emerged as a non-invasive pharmacological alternative. Understanding the comparative efficacy of these two treatments is important for optimizing patient care.
View Article and Find Full Text PDFLeflunomide can be used in management of psoriatic disease. Leflunomide's active metabolite, teriflunomide, is used in the treatment of multiple sclerosis and has unexpectedly been rarely reported to induce pustular psoriasis. In this report, we present a patient with multiple sclerosis who developed inverse psoriasis after starting teriflunomide.
View Article and Find Full Text PDFArticle Synopsis
- - This study explores the relationship between mild cognitive impairment (MCI), a potential precursor to Alzheimer's disease, and articulatory precision in speech by introducing a new measure called the phoneme log-likelihood ratio (PLLR).
- - Researchers analyzed speech recordings from various groups, including cognitively unimpaired individuals and those with MCI or dementia, and found that MCI and dementia participants displayed reduced speech fluency and pace.
- - The PLLR demonstrated strong effectiveness in distinguishing between cognitively unimpaired participants and those with cognitive decline, highlighting its potential as a sensitive tool for detecting early changes in speech related to cognitive health.
Dear Editor, we read the article "Sarcopenia Prevalence Among Hospitalized Patients with Severe Obesity: An Observational Study" and found it to be of great interest. The exploration of this important topic is highly commendable; however, we would like to highlight a critical issue that has not been fully addressed in this study. Specifically, the study does not fully adhere to the consensus definition of sarcopenic obesity (SO) as outlined by the European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO), as we will explain below.
View Article and Find Full Text PDFPurpose: Adults with arthritis experience poor health-related quality of life (HRQOL), though research often focuses on single HRQOL outcomes or summary scores. We aimed to identify HRQOL profiles in adults with different arthritis types and determine risk and protective factors.
Methods: Data including PROMIS-29 Profile v2.