Publications by authors named "K D Miteva"
Article Synopsis
- The study identifies seven microRNAs (miRNAs) that inhibit the proliferation of vascular smooth muscle cells (vSMCs), important in preventing vascular remodeling issues.
- Through high-throughput screening of 2,042 human miRNA mimics, the researchers pinpointed miR-323a-3p, miR-449b-5p, miR-491-3p, miR-892b, miR-1827, miR-4774-3p, and miR-5681b as effective in reducing vSMC proliferation.
- The findings suggest these miRNAs could be developed into therapeutic agents, particularly for conditions like vein graft failure, showing minimal toxicity and altering key cell-cycle gene networks involved in
Background: Age and sex are prominent risk factors for heart failure and determinants of structural and functional changes of the heart. Cardiac fibroblasts (cFB) are beyond their task as extracellular matrix-producing cells further recognized as inflammation-supporting cells. The present study aimed to evaluate the impact of sex and age on the inflammatory potential of cFB and its impact on the cardiosplenic axis and cardiac fibrosis.
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