Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes.

Aim: Somatostatin from pancreatic δ-cells is a paracrine regulator of insulin and glucagon secretion, but the release kinetics and whether secretion is altered in diabetes is unclear. This study aimed to improve understanding of somatostatin secretion by developing a tool for real-time detection of somatostatin release from individual pancreatic islets.

Methods: Reporter cells responding to somatostatin with cytoplasmic Ca concentration ([Ca]) changes were generated by co-expressing somatostatin receptor SSTR2, the G-protein Gα15 and a fluorescent Ca sensor in HeLa cells.

Spectroscopic approach to optimize the biogenic silver nanoparticles for photocatalytic removal of ternary dye mixture and ecotoxicological impact of treated wastewater.

The fabricating of extremely effective, economical, ecologically safe, and reusable nanoparticle (NP) catalysts for the removal of water pollution is urgently needed. This study, spectroscopically optimizes the process parameters for the biogenic synthesis of AgNP catalysts using Cledrdendrum infortunatum leaf extract. The optimization of several synthesis parameters was systematically studied using UV-Vis spectroscopy to identify the ideal conditions for AgNPs formation.

Submicromolar fluorescence 'turn-on' detection of fluoride anions using -(tetra-aryl) calix[4]pyrrole.

-(tetra-aryl) picket calix[4]pyrrole 1 featuring -fluorophenyl groups at all four -positions in a -configuration has been synthesized and characterized unambiguously using single-crystal X-ray diffraction analysis. This pre-organized system possesses a deep binding pocket created by the four aryl groups so that anions can be accommodated through anion-π interactions and four-point N-H⋯anion hydrogen bonds. Single-crystal X-ray diffraction analysis of the CsF and TEAF (TEA = tetraethylammonium) complexes of receptor 1 unequivocally confirms the formation of 1 : 1 complexes, revealing the binding modes in the solid state.

Charge noise in low Schottky barrier multilayer tellurium field-effect transistors.

Creating van der Waals (vdW) homojunction devices requires materials with narrow bandgaps and high carrier mobilities for bipolar transport, which are crucial for constructing fundamental building blocks like diodes and transistors in a 2D architecture. Following the recent discovery of elemental 2D tellurium, here, we systematically investigate the electrical transport and flicker noise of hydrothermally grown multilayer tellurium field effect transistors. While the devices exhibit a dominant p-type behavior with high hole mobilities up to ∼242 cm V s at room temperature and almost linear current-voltage characteristics down to 77 K, ambipolar behavior was observed in some cases.

Tetra-benzimidazoles flanking divinyl-phenothiazine: AIEgens as aza-Michael acceptors in concentration-tuned responses to biogenic amine vapors.

Tetra-benzimidazole rotors flanking a divinyl-phenothiazine stator are realized as red AIEgens and newly identified as efficient aza-Michael acceptors for the identification of biogenic amine vapors. Weakly red-emissive solids display a blue-shifted turn-on emission by rapid aza-Michael addition and simultaneous reverse Knoevenagel reactions. Concentration variation imposes better crystallinity and facilitates radiative decay, offering distinct emissions.