Publications by authors named "K D Luc"
Rheumatoid arthritis (RA) is a chronic inflammatory disease manifested by joint involvement, extra-articular manifestations, and general symptoms. Adipose tissue, previously perceived as an inert energy storage organ, has been recognised as a significant contributor to RA pathophysiology. Adipokines modulate immune responses, inflammation, and metabolic pathways in RA.
View Article and Find Full Text PDFExposure to ambient air pollution influences cardiovascular (CV) morbidity and mortality. The differential effects of changing particulate or gaseous air pollution on endothelial function in young healthy individuals remain unclear. The aim of this study was to evaluate the relationships between exposures to different pollutants and vascular function in a group of 39 young (33±11 years old) subjects with low CV risk.
View Article and Find Full Text PDFArticle Synopsis
- Poisoning and overdose are critical issues in medicine and toxicology, requiring adherence to emergency medicine principles and effective antidote use to manage patient care.
- Modern research has led to the creation of new antidotes, which are essential for accelerating toxin elimination, particularly in regions with limited intensive care resources.
- The article reviews various antidotes, their biochemical profiles, usage scenarios, dosage guidelines, mechanisms of action, and alternative applications, like using -acetylcysteine for COVID-19 treatment.
Oxidative stress and inflammatory markers in prediabetes and diabetes.
J Physiol Pharmacol
December 2019
Prediabetes is a state of elevated plasma glucose in which the threshold for diabetes has not yet been reached and can predispose to the development of type 2 diabetes and cardiovascular diseases. Insulin resistance and impaired beta-cell function are often already present in prediabetes. Hyperglycemia can upregulate markers of chronic inflammation and contribute to increased reactive oxygen species (ROS) generation, which ultimately cause vascular dysfunction.
View Article and Find Full Text PDFBackground And Purpose: Hypertension is a multifactorial disease, manifested by vascular dysfunction, increased superoxide production, and perivascular inflammation. In this study, we have hypothesized that 1,2,3,4,6-penta-O-galloyl-β-d-glucose (PGG) would inhibit vascular inflammation and protect from vascular dysfunction in an experimental model of hypertension.
Experimental Approach: PGG was administered to mice every 2 days at a dose of 10 mg·kg i.