Publications by authors named "K D Leedy"

Article Synopsis
  • * In healthy host cells, NLRX1 acts as a tumor suppressor, slowing down tumor growth and lung metastasis by inhibiting certain tumor characteristics.
  • * In contrast, in tumor cells like 4T1, NLRX1 facilitates cancer aggressiveness and spread by enhancing key processes like cell migration and metabolism.
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Article Synopsis
  • * NLRX1's role in cancer is complex; it can act as both a promoter and suppressor of tumors, depending on the cell type and context.
  • * Research shows that NLRX1 can lead to increased cell death and reduced growth and spread of pancreatic cancer cells, possibly by affecting key signaling pathways related to inflammation and energy production.
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Zinc oxide (ZnO) is an attractive material for microscale and nanoscale devices. Its desirable semiconductor, piezoelectric and optical properties make it useful in applications ranging from microphones to missile warning systems to biometric sensors. This work introduces a demonstration of blending statistics and chemical etching of thin films to identify the dominant factors and interaction between factors, and develop statistically enhanced models on etch rate and selectivity of c-axis-oriented nanocrystalline ZnO thin films.

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VO-based MEMS tunable optical shutters are demonstrated. The design consists of a VO-based cantilever attached to a VO-based optical window with integrated resistive heaters for individual mechanical actuation of the cantilever structure, tuning of the optical properties of the window, or both. Optical transmittance measurements as a function of current for both heaters demonstrates that the developed devices can be used as analog optical shutters, where the intensity of a light beam can be tuned to any value within the range of VO phase transition.

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Heterogeneous integration strategies are increasingly being employed to achieve more compact and capable electronics systems for multiple applications including space, electric vehicles, and wearable and medical devices. To enable new integration strategies, the growth and transfer of thin electronic films and devices, including III-nitrides, metal oxides, and 2D materials, using 2D boron nitride (BN)-on-sapphire templates are demonstrated. The van der Waals (vdW) BN layer, in this case, acts as a preferred mechanical release layer for precise separation at the substrate-film interface and leaves a smooth surface suitable for vdW bonding.

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