Publications by authors named "K D Hankenson"
The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome-wide association study (GWAS) efforts for childhood obesity revealed 19 independent signals for the trait; however, the mechanism of action of these loci remains to be elucidated. To molecularly characterize these childhood obesity loci, we sought to determine the underlying causal variants and the corresponding effector genes within diverse cellular contexts.
View Article and Find Full Text PDFCirculating monocytes infiltrate and coordinate immune responses in tissues surrounding implanted biomaterials and in other inflamed tissues. Here we show that immunometabolic cues in the biomaterial microenvironment govern the trafficking of immune cells, including neutrophils and monocytes, in a manner dependent on the chemokine receptor 2 (CCR2) and the C-X3-C motif chemokine receptor 1 (CX3CR1). This affects the composition and activation states of macrophage and dendritic cell populations, ultimately orchestrating the relative composition of pro-inflammatory, transitory and anti-inflammatory CCR2, CX3CR1 and CCR2 CX3CR1 immune cell populations.
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- * A promising alternative is a 3D porous scaffold made with fused filament fabrication (FFF) technology combined with silver-doped bioactive glass-ceramic particles, which shows potential for helping bone regeneration and has antibacterial properties.
- * The study evaluates the mechanical strength and antibacterial effectiveness of these scaffolds through various tests, demonstrating they are not only strong but also support cell growth, making them a viable solution for bone repair.
Article Synopsis
- Genome-wide association studies (GWAS) have identified genetic links to autoimmune disorders but don't pinpoint causal variants or affected cell types; this research enhances understanding using advanced 3D genomic datasets.
- By integrating various genomic techniques, the study maps disease-associated variants to likely regulatory effector genes across 57 human cell types, revealing the complex genetic landscape of autoimmune diseases.
- The investigation identifies both shared and specific genetic pathways, leading to the exploration of squalene synthase as a potential drug target for controlling inflammation in conditions like multiple sclerosis and systemic lupus erythematosus.
Thrombospondin-1 (TSP1) is a matricellular protein associated with the regulation of cell migration through direct binding interactions with integrin proteins and by associating with other receptors known to regulate integrin function, including CD47 and CD36. We previously demonstrated that deletion of an epithelial TSP1 receptor, CD47, attenuates epithelial wound repair following intestinal mucosal injury. However, the mechanisms by which TSP1 contributes to intestinal mucosal repair remain poorly understood.
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