Publications by authors named "K D Griffiths"
Offspring of older breeders frequently show reduced longevity, which has been linked to shorter offspring telomere length. It is currently unknown whether such telomere reduction persists beyond a single generation, as would be the case if germline transmission is involved. In a within-grandmother, multi-generational study using zebra finches, we show that the shorter telomeres observed in F1 offspring of older mothers are still present in the F2 generation even when the breeding age of their F1 mothers is young.
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- Aboriginal and Torres Strait Islander women in New South Wales experience significantly higher rates of cervical cancer compared to non-Aboriginal women, with an incidence rate of 17.29 per 100,000 versus 6.77 per 100,000.
- Despite similar overall treatment rates and survival outcomes, Aboriginal women often face barriers to surgical and radiotherapy treatments, especially if they are socioeconomically disadvantaged or live in remote areas.
- There is a pressing need for targeted interventions to improve access to cervical cancer care for younger Aboriginal women, addressing issues related to diagnosis, treatment, and the broader socioeconomic impacts of the disease.
Despite many diagnostic and therapeutic advances, colorectal cancer (CRC) remains the second leading cause of cancer death for men and women in the United States. Alarmingly, for reasons currently unknown, the demographics of this disease have shifted towards a younger population. Hence, understanding the molecular mechanisms underlying CRC initiation and progression and leveraging these findings for therapeutic purposes remains a priority.
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- Heatwaves are increasing in frequency and duration, yet there is a lack of accessible environmental data for primary care use; this study aims to create an online mapping tool to help assess community vulnerability to heatwaves.
- Conducted as a participatory action-research project in France, the study engaged key stakeholders, including primary care practitioners and data scientists, to collaboratively identify data variables affecting heatwave vulnerability.
- The findings indicate the importance of co-creating tools that integrate environmental data into primary care, highlighting the potential to enhance health assessments and address broader planetary health issues.
The first international consensus guideline on physiological interpretation of cardiotocograph (CTG) produced by 44 CTG experts from 14 countries was published in 2018. This guideline ensured a paradigm shift from classifying CTG by arbitrarily grouping certain features of the fetal heart rate into different "categories", and then, randomly combining them to arrive at an overall classification of CTG traces into "Normal, Suspicious and Pathological" (or Category I, II and III) to a classification which is based on the understanding of fetal pathophysiology. The guideline recommended the recognition of different types of fetal hypoxia, and the determination of features of fetal compensatory responses as well as decompensation to ongoing hypoxic stress on the CTG trace.
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