Publications by authors named "K D Friesgaard"
Article Synopsis
- Postoperative pain management is challenging for patients undergoing robot-assisted cystectomy, and researchers studied whether a single dose of intraoperative methadone could help reduce pain and the need for opioids post-surgery.
- In a clinical trial with 114 patients, those receiving methadone had similar opioid requirements compared to those getting morphine at both 3 and 24 hours after surgery, but pain levels were lower in the morphine group at 48 hours.
- Patient satisfaction was higher for those given methadone at 24 hours, indicating that while methadone didn't reduce opioid use or pain intensity, it may contribute to greater overall satisfaction.
Background: Laparoscopic hysterectomy is often carried out as day-stay surgery. Minimising postoperative pain is therefore of utmost importance to ensure timely discharge from hospital. Methadone has several desirable pharmacological features, including a long elimination half-life.
View Article and Find Full Text PDFIntroduction: The Italian Medieval doctor Thaddeus Florentinus (AD 1210-1295) claimed that herbs could cure or relieve various symptoms such as obstipation, melancholia and nervousness. Additionally, certain herbs were proposed to be able to predict the weather and induce the vision of elves. Therefore, the aim of this study was to investigate whether herbs could have medical properties as claimed.
View Article and Find Full Text PDFIntroduction: Acute pain is a frequent symptom among patients in the pre-hospital setting, and opioids are the most widely used class of drugs for the relief of pain in these patients. However, the evidence base for opioid use in this setting appears to be weak. The aim of this systematic review was to explore the efficacy and safety of opioid analgesics in the pre-hospital setting and to assess potential alternative therapies.
View Article and Find Full Text PDFMethadone is an opioid with several desirable pharmacological features, including a long elimination half-life. Several studies have suggested that a single intraoperative dose reduces post-operative pain and opioid consumption. In this review, we summarise the current knowledge of intraoperative methadone for the treatment of post-operative pain and propose recommendations for clinical use and future research.
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