Biomarkers.

Background: Circulating plasma total tau (t-tau) concentrations are increasingly being utilized for Alzheimer's disease (AD) diagnoses. Nonetheless there is a dearth of data on the use of t-tau in diverse groups, including Hispanic populations who are at elevated risk for AD. Therefore, we investigated the feasibility of biomarker data availability in diverse groups and subsequently assessed the relationship between t-tau with mild cognitive impairment (MCI) and AD/dementia in Hispanic participants across multiple datasets available via the Global Alzheimer's Association Interactive Network (GAAIN).

Deciphering Colorectal Cancer-Hepatocyte Interactions: A Multiomic Platform for Interrogation of Metabolic Crosstalk in the Liver-Tumor Microenvironment.

Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to adapt to and exploit their microenvironment for sustained growth. The liver is a common site of metastasis, but the interactions between tumor cells and hepatocytes remain poorly understood. In the context of liver metastasis, these interactions play a crucial role in promoting tumor survival and progression.

Compassionate access to virus-specific T cells for adoptive immunotherapy over 15 years.

Adoptive T-cell immunotherapy holds great promise for the treatment of viral complications in immunocompromised patients resistant to standard anti-viral strategies. We present a retrospective analysis of 78 patients from 19 hospitals across Australia and New Zealand, treated over the last 15 years with "off-the-shelf" allogeneic T cells directed to a combination of Epstein-Barr virus (EBV), cytomegalovirus (CMV), BK polyomavirus (BKV), John Cunningham virus (JCV) and/or adenovirus (AdV) under the Australian Therapeutic Goods Administration's Special Access Scheme. Most patients had severe post-transplant viral complications, including drug-resistant end-organ CMV disease, BKV-associated haemorrhagic cystitis and EBV-driven post-transplant lymphoproliferative disorder.

Global Data Compilation Across Climate Gradients Supports the Use of Common Allometric Equations for Three Transatlantic Mangrove Species.

Predicting the distribution, structure, and biomass of mangrove forests is an area of high research interest. Across the Atlantic East Pacific biogeographic region, three species are common and abundant members of local mangrove communities; , , and . Biomass prediction for these species has relied on two approaches: site-specific allometries based on the idea that environmental/climatic differences between sites drive growth differences, or the use of common allometric equations based on the idea that site driven differences are minimal.

Patterns of depression symptoms in relation to stressors and social behaviors during the COVID-19 pandemic among older youth and emerging adults in the United States.

Substantial increases in depression at the outset of the pandemic were previously reported in NCANDA, a longitudinal sample of adolescents and young adults. The current NCANDA study examined depression symptoms before and during the COVID-19 pandemic. It evaluated the influence of stressors and social behavior (e.