Publications by authors named "K Cousins"
Background: Lewy body disorders (LBD), encompassing Parkinson disease (PD), PD dementia (PDD), and dementia with Lewy bodies (DLB), are characterized by alpha-synuclein pathology but often are accompanied by Alzheimer's disease (AD) neuropathological change (ADNC). The medial temporal lobe (MTL) is a primary locus of tau accumulation and associated neurodegeneration in AD. However, it is unclear the extent to which AD copathology in LBD (LBD/AD+) contributes to MTL-specific patterns of degeneration.
View Article and Find Full Text PDFBackground: We describe the Alzheimer's Disease Neuroimaging Initiative (ADNI) Biomarker Core major activities from October 2004 to March 2024, including biobanking ADNI cerebrospinal fluid (CSF), plasma, and serum biofluid samples, biofluid analyses for Alzheimer's disease (AD) biomarkers in the Biomarker Core and various non-ADNI laboratories, and continuous assessments of pre-analytics.
Results: Validated immunoassay and mass spectrometry-based assays were performed in CSF with a shift to plasma, a more accessible biofluid, as qualified assays became available. Performance comparisons across different CSF and plasma AD biomarker measurement platforms have enriched substantially the ADNI participant database enabling method performance determinations for AD pathology detection and longitudinal assessments of disease progression.
Article Synopsis
- Behavioral variant frontotemporal dementia (bvFTD) is primarily linked to tau or TDP-43 protein accumulation, and the study aimed to investigate how these proteinopathies cause different patterns of neurodegeneration in the brain's cortical layers.
- Researchers compared the distribution of pyramidal neuron degeneration in individuals with bvFTD-tau (27 subjects), bvFTD-TDP (47 subjects), and healthy controls (32 subjects) across various cytoarchitectonic types in the frontal cortex.
- Findings indicated that while SMI32 immunoreactivity (a measure of neuron health) decreased uniformly in bvFTD-TDP, there was a significant progressive loss in bvFTD-tau, especially in the supragranular
Objectives: To compare parent/carer proxy-reported dental caries experience of their 5-year-old child with epidemiological survey clinician examination of caries experience in the same children. To determine any differences in the accuracy by area-based socioeconomic group.
Methods: A cross-sectional data linkage study linked data from the Growing Up in Scotland (GUS) study and the National Dental Inspection Programme (NDIP) school epidemiology survey.