Publications by authors named "K Cortas"
Background: Interaction of P-selectin with its glycoprotein ligand (P-selectin glycoprotein ligand type 1) mediates inflammatory processes that may also include vascular thrombosis. Platelet P-selectin expression is increased in patients with coronary heart disease, and its antagonism represents a potential future therapeutic target for the prevention and treatment of atherothrombosis.
Aim: To investigate the effects of the novel small molecule P-selectin antagonist PSI-697 on thrombus formation in humans.