Publications by authors named "K Coombe"
Chemotherapy agents have been shown to induce the transcription factor nuclear factor-kappaB (NF-kappaB) and subsequent chemoresistance in fibrosarcomas and other cancers. The mechanism of NF-kappaB-mediated chemoresistance remains unclear, with a previous report suggesting that doxorubicin induces this response independent of the inhibitory kappaB kinases (IKK). Other studies have indicated that IKKbeta, but not IKKalpha, is required.
View Article and Find Full Text PDFObjectives: Carboplatin skin testing (ST) can help identify patients with platinum hypersensitivity (PH), however, we have encountered patients who do not immediately test positive yet exhibit subtle or delayed allergy symptoms prior to PH. We describe the "atypical platinum reactions" (APH) of 14 patients and our experience with skin testing and desensitization.
Methods: Retrospective chart review was performed on carboplatin-treated patients.
Article Synopsis
- The study investigates how cholecystokinin-8 affects the onset of acute edematous pancreatitis in dogs by looking at changes in pancreatic enzymes and structure.
- Cholecystokinin-8 infusion leads to significant increases in various pancreatic enzymes and noticeable swelling and fluid buildup in the pancreas within 2 hours.
- The activation of trypsinogen occurs quickly but is brief, while levels of amylase and lipase continue to rise, highlighting the complex nature of pancreatitis development.