Publications by authors named "K Cooke"
Type 2 diabetes is preceded by a defective insulin response, yet our knowledge of the precise mechanisms is incomplete. Here, we investigate how insulin resistance alters skeletal muscle signaling and how exercise partially counteracts this effect. We measured parallel phenotypes and phosphoproteomes of insulin-resistant (IR) and insulin-sensitive (IS) men as they responded to exercise and insulin (n = 19, 114 biopsies), quantifying over 12,000 phosphopeptides in each biopsy.
View Article and Find Full Text PDFArticle Synopsis
- Commercial fishermen face numerous health risks due to harsh working conditions, irregular lifestyles, and high levels of stress, which affect their productivity and overall well-being.
- Despite their critical role in the Blue Economy, there is a lack of public data on the cardiometabolic health and behaviors of fishermen in Rhode Island.
- A comprehensive research framework is being implemented to investigate these health issues and identify interventions aimed at improving the quality of life and health outcomes for commercial fishermen.
Background: Weight loss can improve the metabolic complications of obesity. However, it is unclear whether insulin resistance persists despite weight loss and whether any protective benefits are preserved following weight regain (weight cycling). The impact of genetic background on weight cycling is undocumented.
View Article and Find Full Text PDFUnlabelled: Mitochondria facilitate thousands of biochemical reactions, covering a broad spectrum of anabolic and catabolic processes. Here we demonstrate that the adipocyte mitochondrial proteome is markedly altered across multiple models of insulin resistance and reveal a consistent decrease in the level of the mitochondrial processing peptidase miPEP.
Objective: To determine the role of miPEP in insulin resistance.
Nutrition is vital to the long-term survival of children undergoing blood and marrow transplantation (BMT), but there is no standardization on how to optimize the nutritional status of these patients. A literature search was performed to evaluate nutritional support approaches currently in practice for pediatric patients who are undergoing BMT. CINAHL, Embase, and Cochrane databases were searched for peer-reviewed articles evaluating nutritional interventions for BMT recipients aged 20 or younger.
View Article and Find Full Text PDF