Publications by authors named "K Cianflone"
Adipose tissue, as an endocrine organ, secretes several adipocyte-derived hormones named 'adipokines' that are implicated in regulating energy haemostasis. Substantial evidence shows that white adipose tissue-derived adipokines mediate the link between obesity-related exogenous factors (like diet and lifestyle) and various biological events (such as pre- and postmenopausal status) that have obesity consequences (cardiometabolic disorders). One of the critical aetiological factors for obesity-related diseases is the dysfunction of adipokine pathways.
View Article and Find Full Text PDFThe Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome.
Front Endocrinol (Lausanne)
June 2019
Atorvastatin has been shown to improve cardiovascular risk (CVR) indices in women with polycystic ovary syndrome (PCOS). Low-grade chronic inflammation of adipose tissue may link PCOS and adverse CVR. In pro-inflammatory states such as PCOS, spontaneous activation of the alternative pathway of complement results in increased generation of acylation stimulating protein (ASP) from adipocytes irrespective of body mass index.
View Article and Find Full Text PDFCardiac dysfunction can be a fatal complication during severe sepsis. The migration of neutrophils is significantly impaired during severe sepsis. We sought to determine the role of trimetazidine (TMZ) in regulation of neutrophil migration to the heart in a mouse model of sepsis and endotoxemia, and to identify the mechanism whereby TMZ confers a survival advantage.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates the link between circulating steroid hormone levels and increased body fat in premenopausal women, focusing on how obesity may alter these hormone profiles.
- The research involved 42 women, measuring 19 plasma steroids and assessing body fat distribution through advanced imaging techniques.
- Findings revealed negative correlations between certain steroid levels (like androstenedione and pregnenolone) and indicators of adiposity, suggesting that low levels of these hormones may be associated with fat tissue dysfunction and increased inflammation.
Article Synopsis
- Obesity is linked to chronic low-grade inflammation (metaflammation), which the study investigates by looking at how the protein C5a affects inflammation and insulin resistance in fat cells (3T3-L1 adipocytes).
- Researchers treated these adipocytes with C5a and another inflammatory agent, lipopolysaccharide (LPS), then measured levels of specific inflammatory substances and analyzed signaling pathways related to inflammation and insulin response.
- Results showed that C5a increased inflammation in the adipocytes and decreased their ability to take up glucose, indicating that C5a exacerbates insulin resistance through specific inflammatory signaling pathways.