Role of sclerostin in mastocytosis bone disease.

Mastocytosis is a heterogeneous group of disorders, characterized by accumulation of clonal mast cells which can infiltrate several organs, most often spine (70%). The pathogenesis of mastocytosis bone disease is poorly understood. The main aim of the study was to investigate whether neoplastic mast cells may be the source of sclerostin and whether there is an association between sclerostin and selected bone remodeling markers with mastocytosis related bone disease.

Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men.

The aim of this study was to test the utility of haemodynamic and autonomic variables (e.g. peripheral chemoreflex sensitivity [PCheS], blood pressure variability [BPV]) for the prediction of individual performance (marathon time and VO) in older men.

Distribution of Plantar Pressure in Soccer Players.

(1) Background: The aim of this study was to evaluate differences in the static and dynamic distribution of foot pressure on the ground and to investigate the relationships between body mass index (BMI) and mean variables of plantar pressure between soccer players and their non-athlete peers. (2) Methods: The study involved 18 first-division Polish soccer players and 30 non-athlete physiotherapy students. The research experiment was conducted using the FreeMed platform.

Real-World Efficacy of Midostaurin in Aggressive Systemic Mastocytosis.

In April 2017 midostaurin was approved by the US Food and Drug Administration for the treatment of patients with aggressive systemic mastocytosis (ASM). So far, very limited real world data on its efficacy is available. Thirteen patients aged from 48 to 79 years, who received midostaurin in the early access program, were included in the study.