Publications by authors named "K Chatzistamatiou"
Article Synopsis
- The new molecular classification of endometrial cancer is changing how doctors manage the disease, supported by a recently updated FIGO staging system that includes molecular substages for early-stage cases.
- A study analyzed patient records from a hospital from 2012 to 2023, focusing on stage shifts and treatment outcomes, revealing that 15.5% of patients experienced a shift in their cancer stage, mainly from earlier stages to stage IIC.
- The 2023 FIGO staging system shows improved differentiation of early-stage endometrial cancer prognoses while demonstrating similar prognostic accuracy as the previous 2009 system.
CA-125 KELIM as an Alternative Predictive Tool to Identify Which Patients Can Benefit from PARPi in High-Grade Serous Advanced Ovarian Cancer: A Retrospective Pilot Diagnostic Accuracy Study.
Int J Mol Sci
May 2024
BRCA mutation and homologous recombination deficiency (HRD) are the criteria for the administration of PARP inhibitor (PARPi) maintenance therapy. It is known that PARPi efficacy is related to platinum sensitivity and that the latter can be demonstrated from the CA-125 elimination rate constant (KELIM). This study aims to investigate if KELIM can be another tool in the identification of patients that could be benefit from PARPi therapy.
View Article and Find Full Text PDF(1) Background: Neoadjuvant chemotherapy followed by interval debulking surgery is used in the treatment of advanced ovarian cancer. However, no tool can safely predict if complete cytoreduction after 3-4 cycles can be achieved. This study aims to investigate if the KELIM score can be a triage tool in the identification of patients that will be ideal candidates for interval debulking surgery (IDS).
View Article and Find Full Text PDFIncreasing evidence supports a role for the vaginal microbiome (VM) in the severity of HPV infection and its potential link to cervical intraepithelial neoplasia. However, a lot remains unclear regarding the precise role of certain bacteria in the context of HPV positivity and persistence of infection. Here, using next generation sequencing (NGS), we comprehensively profiled the VM in a series of 877 women who tested positive for at least one high risk HPV (hrHPV) type with the COBAS 4,800 assay, after self-collection of a cervico-vaginal sample.
View Article and Find Full Text PDFObjective: To identify the optimal strategy for the triage of women who test high-risk (hr) HPV positive on self-collected cervicovaginal samples.
Methods: This is a diagnostic accuracy sub-analysis of the GRECOSELF study, which reported on HPV-DNA testing with self-sampling in Greece. More than 13,000 women, 25-60 years old, who resided in rural areas of Greece, provided a self-collected cervicovaginal sample.