Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development.

The lack of a common exchange format for mathematical models in pharmacometrics has been a long-standing problem. Such a format has the potential to increase productivity and analysis quality, simplify the handling of complex workflows, ensure reproducibility of research, and facilitate the reuse of existing model resources. Pharmacometrics Markup Language (PharmML), currently under development by the Drug Disease Model Resources (DDMoRe) consortium, is intended to become an exchange standard in pharmacometrics by providing means to encode models, trial designs, and modeling steps.

Cytosolic levels and distribution of cadmium, copper and zinc in pretumorous livers from diethylnitrosamine-exposed mice and in non-cancerous kidneys cancer patients.

Exposure of mice to diethylnitrosamine (DEN) in their drinking water, resulted in decreases of Cu and Zn in cytosol of both pretumorous and tumorous liver tissue. Copper was reduced 28% and zinc 44.5% in cytosol of tumorous tissue at the time of death.

Interactions between cadmium and zinc in cytoplasm of duck liver and kidney.

Ducks were collected from a marine environment known to be polluted with heavy metals. Gel elution profiles were determined for both liver and kidney tissue using Sephadex G-75 gel. Zn increased linearly on the high molecular weight protein pool until this pool was apparently Zn saturated; saturation levels were 0.