Changing Treatment and Metastatic Disease Patterns in Patients with EGFR Mutated NSCLC: An Academic Thoracic Medical Investigator's Consortium Registry Analysis.

Introduction: Osimertinib is now a standard first-line (1L) therapy for EGFR-mutated (EGFRm) advanced NSCLC. We aimed to characterize patterns of therapy and longitudinal risk of brain and liver metastasis in a cohort of EGFRm NSCLC.

Methods: Patients with metastatic EGFRm NSCLC who received 1L systemic therapy at sites within the Academic Thoracic Medical Investigator's Consortium were included; demographic and clinical data including treatment patterns were described.

Characteristics of Long-Term Survivors With EGFR-Mutant Metastatic NSCLC.

Introduction: Characteristics of long-term survivors in EGFR-mutant (EGFRm) NSCLC are not fully understood. This retrospective analysis evaluated a multi-institution cohort of patients with EGFRm NSCLC treated in the pre-osimertinib era and sought to describe characteristics of long-term survivors.

Methods: Clinical characteristics and outcomes were abstracted from the electronic medical records of patients with EGFRm metastatic NSCLC who started first-line therapy before 2015.

The response of the frugivorous lion-tailed macaque (Macaca silenus) to a period of fruit scarcity.

Tropical rainforests show seasonal fluctuations in the abundance of fruits resulting in periods of resource scarcity for frugivores. We examined the response of an obligate frugivore, the lion-tailed macaque (LTM) (Macaca silenus), to a period of fruit scarcity in a rainforest in the Western Ghats, India. We estimated the abundance and distribution of fruit resources from food tree densities obtained from 348 point centered quadrats, and fruit availability from phenological monitoring of 195 trees of 15 reported major food species.

Progress in the research of artemisinin and its analogues as antimalarials: an update.

Malaria is the number one infectious disease in the world today. Worldwide, over two million people die each year from malaria. This shocking reality is largely due to the emergence of drug resistant strains of Plasmodium falciparum.

Spontaneous rupture of the stomach.

A case of spontaneous rupture of the stomach associated with perforation of the diaphragm is reported. Spontaneous rupture of the stomach is a rare but fatal condition. The pathophysiologic features, clinical manifestations, and treatment are discussed.