Publications by authors named "K Casper"
Hypothyroidism Predicts Fistula Development Following Salvage Oropharyngectomy.
J Otolaryngol Head Neck Surg
November 2024
Importance: Previous work demonstrated postoperative hypothyroidism adversely affects wound healing in salvage laryngectomy. Currently, no studies have evaluated the association between wound healing and hypothyroidism in patients undergoing salvage oropharyngectomy.
Objective: The primary objective was studying hypothyroidism and other factors associated with oropharyngocutaneous fistula development and fistula requiring reoperation within 30 days after salvage oropharyngectomy.
Article Synopsis
- The study aimed to evaluate the effectiveness of botulinum toxin A injections for managing pharyngoesophageal dysfunction in patients who have undergone laryngectomy, focusing on voice and swallowing restoration.
- A retrospective review of 43 patients was conducted, revealing that most were male and had undergone prior surgical procedures, with a majority experiencing positive improvements in both swallowing and speaking skills post-treatment.
- The results suggest that botulinum toxin A injections are safe and effective, highlighting the need for standardized treatment protocols at healthcare institutions.
Background: Neoadjuvant chemotherapy for induction selection of definitive treatment (IS) protocols have shown excellent outcomes for organ preservation and survival in patients with T3 laryngeal squamous cell carcinoma (LSCC). We seek to evaluate survival and organ preservation outcomes in T4 LSCC patients treated with IS protocols.
Methods: Retrospective cohort of advanced T3 and T4 LSCC patients who underwent IS protocols based upon potential for preserving a functional larynx.
Objective: We evaluated vessel counts in the pharyngeal mucosal margins of patients who underwent salvage laryngectomy to establish whether mucosal vascularity might predict fistula risk.
Study Design: Retrospective cohort.
Setting: Tertiary Medical Center.
Purpose: Patients undergoing head and neck cancer surgery after prior radiation or chemoradiation are at high risk for wound complications. Hypothyroidism is a known risk factor for wound complications, especially fistulae after salvage total laryngectomy. The purpose of this phase II clinical trial is to investigate the effect of perioperative intravenous levothyroxine supplementation on wound complications in patients undergoing salvage total laryngectomy.
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