A Novel Neurofeedback Attentional Enhancement Approach Based on Virtual Reality.

Attention enhancement can not only improve individual's study and work performance, but also help to improve such psychological problems as anxiety and depression. Traditional attention enhancement approaches have high requirements on the external environment, and thus have such limitations as long intervention periods, high costs, poor universality, and insignificant therapeutic effects. Virtual Reality (VR) can provide interactive and immersive environments, which can help to break through these limitations and effectively enhance users' attention.

Large-scale assessment of polyglutamine repeat expansions in Parkinson disease.

Objectives: We aim to clarify the pathogenic role of intermediate size repeat expansions of SCA2, SCA3, SCA6, and SCA17 as risk factors for idiopathic Parkinson disease (PD).

Methods: We invited researchers from the Genetic Epidemiology of Parkinson's Disease Consortium to participate in the study. There were 12,346 cases and 8,164 controls genotyped, for a total of 4 repeats within the SCA2, SCA3, SCA6, and SCA17 genes.

TREM2 R47H variant and risk of essential tremor: a cross-sectional international multicenter study.

Introduction: Essential tremor (ET) is the most frequent movement disorder in adults. Its pathophysiology is not clearly understood, however there is growing evidence showing common etiologic factors with other neurodegenerative disorders such as Alzheimer's and Parkinson's diseases (AD, PD). Recently, a rare p.

A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants.

Background: Two recent studies identified a mutation (p.Asp620Asn) in the vacuolar protein sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease . Although additional missense variants were described, their pathogenic role yet remains inconclusive.