Publications by authors named "K C Walters"
Background: People living with alcohol use disorder (AUD) who develop Type 2 Diabetes (T2DM) may be at higher risk of diabetes-complications.
Aim: Our aims were to compare diabetes-monitoring and incidence of diabetes-complications between people with and without AUD prior to T2DM diagnosis attending primary care in England.
Design & Setting: We used the Clinical Practice Research Datalink (CPRD) Aurum linked with Hospital Episode Statistics (HES) and Office for National Statistics (ONS) mortality data.
E6AP/UBE3A is the founding member of the HECT (Homologous to the E6-AP Carboxyl Terminus) ubiquitin E3 ligase family, which add ubiquitin post-translationally to protein substrates. E6AP has been structurally defined in complex with human papillomavirus (HPV) oncoprotein E6 and its gain-of-function substrate tumor suppressor p53; however, there is currently no report of E6AP being expressed and purified from mammalian cells, as studies to date have isolated E6AP from E. coli or insect cells.
View Article and Find Full Text PDFPurpose: Cancer survivors in a state with no legal access to cannabis may be hesitant to discuss their cannabis use with providers, particularly in light of legal consequences which disproportionately affect certain racial groups. This study examined potential racial disparities in the relationship of cannabis use status with patient-provider discussions of and attitudes toward cannabis in a state where there is no legal cannabis marketplace.
Methods: Survivors of cancer (N = 1003, M = 62.
Article Synopsis
- UBE3A/E6AP expression abnormalities are linked to neurological disorders like Angelman syndrome and autism, with three protein isoforms existing that have unique functions and cellular roles.
- Research shows the isoforms differ structurally, particularly in their N-terminal regions, affecting their ability to bind to the proteasome and multimerize, which is crucial for their proper activation.
- Advanced techniques, including NMR spectroscopy, reveal that some isoforms have dynamic features that could influence their response to oxidative stress, enhancing the understanding of UBE3A's functions and potential therapeutic targets for related disorders.
Objectives: To validate codelists for defining a range of mental health (MH) conditions with primary care data, using a mixed qualitative and quantitative approach and without requiring external data.
Methods: We validated Read codelists, selecting and classifying them in three steps. The qualitative step included an in-depth revision of the codes by six doctors.