Publications by authors named "K C Vasanthakumar"
Two lipid sensors, CD36 and GPR120, are crucial for the orosensory detection of fat taste and for mediating fat preference. However, the mechanism by which endogenous lipid (FAHFA) binds to CD36 to initiate intracellular signaling remains unexplained. Hence, the primary objective of this study is to investigate the binding mechanism of FAHFA to CD36 and its role in isolated mouse taste bud cells (mTBCs).
View Article and Find Full Text PDFGenetic variations in taste receptors are associated with gustatory perception and obesity, which in turn affects dietary preferences. Given the increasing tendency of people with obesity choosing sweet, high-fat meals, the current study assessed the cross-regulation of two polymorphisms of the sweet taste receptor (T1R2/T1R3), rs35874116 and rs307355, on fat sensitivity in Indian adults. We investigated the association between taste sensitivity and BMI in the T1R2, T1R3, and CD36 polymorphic and non-polymorphic groups.
View Article and Find Full Text PDFArticle Synopsis
- Gustin is a factor that helps our taste buds develop, and a specific gene change (rs2274333) can affect how we taste things, especially bitter stuff like PROP and types of fats.
- Researchers tested 178 healthy people to see how sensitive they were to the taste of fat and bitterness and found that the genetic changes related to taste and body weight were important.
- People with certain genetic types were better at tasting fat and had more taste buds, which means their taste abilities were linked to their genes and how their bodies handle weight.
Insights on the functional dualism of nitric oxide in the hallmarks of cancer.
Biochim Biophys Acta Rev Cancer
November 2023
Article Synopsis
- Nitric oxide (NO) is a gaseous radical that plays significant roles in various physiological and pathological processes, such as cancer, inflammation, and blood vessel dilation.
- The production of NO is carried out by nitric oxide synthases (NOS), which include two constitutive forms (nNOS and eNOS) and an inducible form (iNOS), along with a non-enzymatic pathway involving nitrate and nitrite.
- NO has both anti- and pro-oxidant properties that can influence cancer dynamics by affecting tumor growth through mechanisms like metabolism, DNA repair, and angiogenesis, depending on its concentration and how it's released over time.
There is a lack of research on the combined effects of genetic variations (specifically CD36 SNPs-rs1761667 and rs1527483), dietary food habits (vegetarian or not), and the salivary environment on obesity and taste sensitivity, especially in the Indian population. The current study aims to better understand the relationship between impaired taste perception, fat consumption, higher BMI and obesity development by examining the combined association between CD36 SNPs, oleic acid (OA) detection threshold, and food habits among Indian participants. Furthermore, the relationship between oral fatty acid (FAs) sensitivity and taste physiology factors linked to inflammation and salivary proteins was considered.
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