Publications by authors named "K C Sze"
Background: Digital health has become essential for effective clinical practice. However, the successful adoption of digital health is dependent on the strength of the patient-physician relationship. The patient-physician relationship shapes the quality of care and impacts health care outcomes, especially in primary care.
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- HCC (Hepatocellular Carcinoma) is a leading type of liver cancer, particularly prevalent in China due to high rates of HBV (Hepatitis B Virus) infection, which can disrupt tumor-suppressing genes and promote cancer development.
- Researchers utilized various next-generation sequencing (NGS) databases to analyze HBV integration events across different cohorts, tissues, and genetic backgrounds, revealing patterns of integration related to tumor presence.
- The study highlighted specific integration patterns linked to TERT gene activation and developed a scoring system to predict patient outcomes, enhancing our overall understanding of how HBV contributes to liver cancer progression.
Objective: Fat mass and obesity-associated protein (FTO), an eraser of -methyadenosine (m6A), plays oncogenic roles in various cancers. However, its role in hepatocellular carcinoma (HCC) is unclear. Furthermore, small extracellular vesicles (sEVs, or exosomes) are critical mediators of tumourigenesis and metastasis, but the relationship between FTO-mediated m6A modification and sEVs in HCC is unknown.
View Article and Find Full Text PDFBackground & Aims: Hepatocellular carcinoma (HCC) is a heterogeneous cancer with varying levels of liver tumor initiating or cancer stem cells in the tumors. We aimed to investigate the expression of different liver cancer stem cell (LCSC) markers in human HCCs and identify their regulatory mechanisms in stemness-related cells.
Methods: We used an unbiased, single-marker sorting approach by flow cytometry, fluorescence-activated cell sorting, and transcriptomic analyses on HCC patients' resected specimens.