Proteomic changes upon treatment with semaglutide in individuals with obesity.

Obesity and type 2 diabetes are prevalent chronic diseases effectively managed by semaglutide. Here we studied the effects of semaglutide on the circulating proteome using baseline and end-of-treatment serum samples from two phase 3 trials in participants with overweight or obesity, with or without diabetes: STEP 1 (n = 1,311) and STEP 2 (n = 645). We identified evidence supporting broad effects of semaglutide, implicating processes related to body weight regulation, glycemic control, lipid metabolism and inflammatory pathways.

Knowledge, Attitude, and Practice of Providing First Aid by Commercial Motorcyclists: A Cross-Sectional Study.

Introduction: The mortality and morbidity due to road traffic crashes (RTCs) are increasing drastically world-wide. Poor prehospital care management contributes to dismal patient outcomes, especially in low- and middle-income countries (LMICs). This study aimed to assess the knowledge, attitude, and self-reported practice (KAP) of providing first aid for RTC victims by commercial motorcyclists.

Effects of active video games on mental health among college students: a systematic review.

Background: Mental health significantly impacts college students' academic performance and overall happiness. Active video games (AVGs) have gained popularity among college students due to their ample entertainment, and there is growing interest in utilizing them to address mental health issues. However, there has not been a comprehensive summary and systematic review of research on the effects of AVGs on college students' mental health.

Effect of functional training on fundamental motor skills among children: A systematic review.

Objectives: Fundamental motor skills (FMS) are the foundation of children's movement, requiring tailored training and guidance for development. As an emerging training method, functional training is optimistic in promoting the development of children's fundamental motor skills. However, current studies have not assessed the effect of functional training on fundamental motor skills.