Publications by authors named "K C S Queiroz"
Background: Population aging and the increase in memory-related diseases have motivated the search for accessible cognitive screening instruments. To develop a digital memory and learning test (DMLT) based on Rey's Auditory Verbal Learning Test (RAVLT) principles to assess cognition in the elderly and identify early cognitive decline.
Methods: The research was divided into two phases: developing the digital test and the experimental phase of comparison with a reference test.
Article Synopsis
- Galapagos giant tortoises, found only in the Galapagos Archipelago, exhibit distinct morphological, behavioral, and genetic traits, prompting debate over their classification as separate species due to recent divergences in their populations.
- A study using advanced genetic methods on 38 tortoises revealed strong evidence against treating all tortoises as a single species; instead, it suggests a complex with at least 9 to potentially 13 distinct species.
- The findings highlight varying levels of speciation, with some tortoise groups being further evolved as separate species than others, underscoring the urgency of conservation efforts for threatened island species.
Background: Pneumococcal meningitis (PM) triggers apoptotic neuronal and progenitor cell death in the hippocampal dentate gyrus (DG), resulting in subsequent cognitive impairment. Microglia play a crucial role in PM-induced hippocampal damage. While the lasting effects of neonatal nutrition on health are well documented, the influence of early-life overfeeding on the host response to neuroinfections remains uncertain.
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- Cancer increases the risk of venous thromboembolism, particularly in glioblastoma cases, highlighting the need for new models to study this issue at a molecular level.
- A novel cancer-on-a-chip model was created to analyze how glioblastoma cells affect blood coagulation by co-culturing glioblastoma spheroids with endothelial cells.
- Results showed that glioblastoma cells significantly heightened blood coagulation, and using anticoagulant drugs like rivaroxaban effectively reduced this coagulation in the model, suggesting its potential for discovering new anticoagulant therapies for glioblastoma and similar cancers.
Extant salamanders are used as modern analogs of early digit-bearing tetrapods due to general similarities in morphology and ecology, but the study species have been primarily terrestrial and relatively smaller when the earliest digit-bearing tetrapods were aquatic and an order of magnitude larger. Thus, we created a 3D computational model of underwater walking in extant Japanese giant salamanders (Andrias japonicus) using 3D photogrammetry and open-access graphics software (Blender) to broaden the range of testable hypotheses about the incipient stages of terrestrial locomotion. Our 3D model and software protocol represent the initial stages of an open-access pipeline that could serve as a "one-stop-shop" for studying locomotor function, from creating 3D models to analyzing the mechanics of locomotor gaits.
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