Publications by authors named "K C Roegner"
Article Synopsis
- The study explores the role of 2,3-bisphosphoglycerate mutase (BPGM) in the kidney, highlighting its upregulation during acute kidney injury in both mice and humans.
- Using a specialized mouse model, researchers found that BPGM is mainly located in the distal nephron and its knockout led to rapid kidney injury and structural damage after just four days.
- The absence of BPGM disrupts crucial metabolic processes, elevating oxidative stress and inflammation while linking stress responses between different parts of the nephron, underscoring its importance in kidney function.
Prolyl hydroxylase inhibitors, polydrug use, and the phosphoproteome.
Acta Physiol (Oxf)
January 2023
Article Synopsis
- Chronic Cyclosporine-A treatment can lead to severe side effects like kidney toxicity and anemia, potentially due to hypoxia.
- The study explored the effects of daprodustat, a hypoxia-inducible factor activator, on kidney toxicity caused by Cyclosporine-A, revealing that daprodustat significantly countered Cyclosporine-A's changes to protein expression and phosphorylation.
- While daprodustat alone had a minimal effect, its combination with Cyclosporine-A notably influenced angiogenesis-related pathways and prevented harmful impacts on blood hemoglobin levels and kidney microcirculation.
This study was designed to evaluate, using preclinical models of non-small cell lung cancer (NSCLC), the growth inhibitory effects of the retinoid X receptor (RXR) agonist bexarotene (LGD1069, Targretin) in combination with cytotoxic agents currently used as standard first-line therapy in advanced disease. Although single-agent bexarotene had modest growth inhibitory effects in several cell lines, efficacy was observed only in the micromolar range (>1muM), which approximates the plasma C(max) measured in pharmacokinetic studies in patients. However, when combined with paclitaxel or vinorelbine, bexarotene produced a concentration-dependent enhancement of the growth inhibitory activities of paclitaxel and vinorelbine.
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