Publications by authors named "K C Oberg"

Introduction: In vertebrate limb morphogenesis, wingless-related integration site (Wnt) proteins and fibroblast growth factors (Fgfs) secreted from the apical ectodermal ridge (AER) coordinate proximodistal outgrowth. Fgfs also sustain sonic hedgehog (Shh) in the zone of polarizing activity (ZPA). Shh directs anteroposterior patterning and expansion and regulates AER-, establishing a positive regulatory feedback loop that is vital in sustaining limb outgrowth.

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Diagnosing ureteral stones with low-dose CT in patients with metal hardware can be challenging because of image noise. The purpose of this study was to compare ureteral stone detection and image quality of low-dose and conventional CT scans with and without deep learning reconstruction (DLR) and metal artifact reduction (MAR) in the presence of metal hip prostheses. Ten urinary system combinations with 4 to 6 mm ureteral stones were implanted into a cadaver with bilateral hip prostheses.

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Complex organic molecules are widespread in different areas of the interstellar medium, including cold areas, such as molecular clouds, where chemical reactions occur in ice. Among the observed molecules are oxygen-bearing organic molecules, which are of high interest given their significant role in astrobiology. Despite the observed rich chemistry, the underlying molecular mechanisms responsible for molecular formation in such cold dilute areas are still not fully understood.

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Article Synopsis
  • FLVCR1 is a protein involved in transporting essential compounds like heme and choline, with mutations linked to serious developmental disorders and neurodegenerative conditions in humans.
  • Researchers identified 30 patients with biallelic FLVCR1 variants who displayed severe developmental issues, including brain malformations and other complications, paralleling symptoms seen in mouse models and conditions like Diamond-Blackfan anemia (DBA).
  • The findings emphasize that FLVCR1 variants could cause a wide range of health problems, underscoring the need for diverse genetic testing and consideration of animal model data in understanding human genetic disorders.
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