Publications by authors named "K C Mueller"
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Background: Cognitive decline is often influenced by Alzheimer's disease (AD) pathology (e.g., beta-amyloid burden) and other pathology (e.
View Article and Find Full Text PDFBackground: Sensitive screening for early Alzheimer's disease (AD)-related cognitive decline are needed. Prior research links high beta-amyloid (Aβ) levels to reduced proper name (PN) retrieval in individuals without cognitive impairment. We examined whether language-related regional tau from PET associated with Logical Memory (LM) proper name recall, accounting for LM covariates.
View Article and Find Full Text PDFBackground: Obstructive hypertrophic cardiomyopathy (HCM) is associated with significant morbidity due to left ventricular outflow tract (LVOT) obstruction. While alcohol septal ablation (ASA) is an established interventional treatment, mavacamten, a novel cardiac myosin inhibitor, has emerged as a non-invasive pharmacological alternative. Understanding the comparative efficacy of these two treatments is important for optimizing patient care.
View Article and Find Full Text PDFLeflunomide can be used in management of psoriatic disease. Leflunomide's active metabolite, teriflunomide, is used in the treatment of multiple sclerosis and has unexpectedly been rarely reported to induce pustular psoriasis. In this report, we present a patient with multiple sclerosis who developed inverse psoriasis after starting teriflunomide.
View Article and Find Full Text PDFArticle Synopsis
- - This study explores the relationship between mild cognitive impairment (MCI), a potential precursor to Alzheimer's disease, and articulatory precision in speech by introducing a new measure called the phoneme log-likelihood ratio (PLLR).
- - Researchers analyzed speech recordings from various groups, including cognitively unimpaired individuals and those with MCI or dementia, and found that MCI and dementia participants displayed reduced speech fluency and pace.
- - The PLLR demonstrated strong effectiveness in distinguishing between cognitively unimpaired participants and those with cognitive decline, highlighting its potential as a sensitive tool for detecting early changes in speech related to cognitive health.